孙海基,男,教授,硕士生导师,博士生导师。2009年毕业于js3845金沙线路生物系获理学博士学位,2007年9月~2008年9月期间,在法国与世界卫生组织肿瘤研究署(IARC)进行课题合作研究。主要从事应激神经生物学、脑科学方面及肿瘤方面的研究。近几年已发表论文40余篇,SCI收录30余篇。主持国家自然科学基金面向项目、国家级公益性行业科研专项子课题、山东省自然科学基金及横向课题等多项。现任js3845金沙线路动物学硕士学位点负责人,动物抗性和疾病团队负责人。高校教材《人体解剖生理学实验教程》及《人体解剖生理学》的副主编,参与编写高教出版社的《人体动物生理学》。为山东省解剖学会常务理事、山东省生理学会常务理事,中文核心期刊《生物医学工程研究》的编委。
研究方向:主要从事应激性胃肠功能功能紊乱的中枢和外周机制的研究。
承担项目:
1、国家自然科学基金委员会,面上项目,31672286,大鼠岛叶-延髓迷走复合体神经环路在束-浸水应激致胃机能紊乱中的作用,2022-01至2025-12,在研,主持。
2、国家自然科学基金面上项目,31672286,:延髓-迷走神经-肠脑环路在束缚-浸水应激致胃肠机能紊乱中的作用,2017/01-2021/12,主持。
3、山东省自然科学基金,ZR2013CM010、迷走复合体星形胶质细胞在束缚-浸水应激致胃黏膜损伤中的作用及与神经元的关系、2013/01-2016/12、主持。
4、国家级公益性行业(农业)科研专项子课题,201303069-07、谷子碎米黄酒生产技术研究与示范-谷子碎米黄酒品质分析及生理功效研究、2013/01-2017/12主持。
5、横向课题中药FKQJ药渣抗菌、抗炎作用的评价分析2014/10-2016/10,主持
教学科研成果
著作:
1《人体及动物生理学》第三版高等教育出版社2015参编
2《生理学实验释疑解难》 科学出版社2007参编
3《人体解剖生理学实验教程》科学出版社2014副主编
4《人体解剖生理学》科学出版社2015副主编
期刊论文:
1、Gao M, Ma H, Liu X, Zhang Y, Tang L, Zheng Z, Zhang X, Jiang C, Lin L, Sun H. Synthesis and Biological Evaluation of Substituted Pyrazole-Fused Oleanolic Acid Derivatives as Novel Selective α-Glucosidase Inhibitors. Chem Biodivers. 2023,三区,通讯作者
2、Gao M, Ma H, Liu T, Cao C, Zheng Z, Tang L, Gu W, Zhang D, Sun H. Acute toxicity and genotoxicity studies on new melatonergic antidepressant GW117. Heliyon. 2023 Feb 24;9(3), 通讯作者
3、Wang Z, Shen Y, Huang C, Wang Y, Zhang X, Guo F, Weng R, Ma X, Sun H. Astrocytes in the spinal cord contributed to acute stress-induced gastric damage via the gap junction protein CX43. Brain Res. 2023 Jul 15;1811:148395. 三区,通讯作者
4、Gao WT, Liu JX, Wang DH, Sun HJ, Zhang XY. Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus). Comp Biochem Physiol C Toxicol Pharmacol. 2023 Aug 21通讯作者
5、Li C, Sun H, Shi Y, Yu Y, Ji X, Li E, Zhou X, Liu X, Xue X, Sun H. Effects of Exogenous Hydrogen Sulfide in the Hypothalamic Paraventricular Nucleus on Gastric Function in Rats. Front Pharmacol. 2022 Jan . 二区,通讯作者
6、Li M, Zhang X, He Q, Chen D, Chen F, Wang X, Sun S, Sun Y, Li Y, Zhu Z, Fang H, Shi X, Yao X, Sun H, Wang M. Functional Interactions Between the Parafascicular Thalamic Nucleus and Motor Cortex Are Altered in Hemiparkinsonian Rat. Front Aging Neurosci. 2022 May 23;14:800159. 二区,通讯作者
7、Wang J, Zhang Q, Xia J, Sun H. Moderate Treadmill Exercise Modulates Gut Microbiota and Improves Intestinal Barrier in High-Fat-Diet-Induced Obese Mice via the AMPK/CDX2 Signaling Pathway. Diabetes Metab Syndr Obes. 2022 Jan 20;15:209-223. 三区,通讯作者
8、Gao W, Wang Z, Wang H, et al. Neurons and Astrocytes in Ventrolateral Periaqueductal Gray Contribute to Restraint Water Immersion Stress-induced Gastric Mucosal Damage via the ERK1/2 Signaling Pathway[J]. The international journal of neuropsychopharmacology. 2021, 24(8): 666-676 ,二区,通讯作者
9、Chen Z , Ding H , Shi Y ,Sun HJ. Exogenous Hydrogen Sulfide Within the Nucleus Ambiguus Inhibits Gastrointestinal Motility in Rats[J]. Frontiers in Physiology, 2020, 11:545184. 二区,通讯作者
10、Zhao D Q , Xue H , Sun H J . Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion[J]. 2020.二区,通讯作者
11、Chen X , Jia Y , Zhang Y , et al. α5‐nAChR contributes to epithelial‐mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer[J]. Journal of Cellular and Molecular Medicine, 2020, 24(4).二区,通讯作者
12、Sun H , Gao W , Li H , et al. Comparative study of the distribution of NOS‐positive neurons in pigeon intestine[J]. Anatomia, Histologia, Embryologia, 2020, 49(4).四区,通讯作者
13、Sun H , Sun X , Wang H , et al. Advances in salt tolerance molecular mechanism in tobacco plants[J]. Hereditas, 2020, 157. 四区,通讯作者
14、Fan F, Yang M, Geng X, et al. Effects of Restraint Water-Immersion Stress-Induced Gastric Mucosal Damage on Astrocytes and Neurons in the Nucleus Raphe Magnus of Rats via the ERK1/2 Signaling Pathway[J]. Neurochemical research, 2019: 1-10. 三区,通讯作者
15、Sun H, Zhao P, Liu W, et al. Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats.[J]. Scientific Reports, 2018, 8(1).三区
16、Astrocytes and Neurons in Locus Coeruleus Mediate Restraint Water Immersion tress-Induced Gastric Mucosal Damage Through the ERK1/2 Signaling Pathway.[J]. Neuroscience Letters, 2018.四区,通讯作者
17、Zhao P , Wang J , Zhao W , et al. Antifatigue and antiaging effects of Chinese rice wine in mice[J]. Food Science & Nutrition, 2018, 6.四区,通讯作者
18、Sun H J, Jia Y F, Ma X L. Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression[J]. Frontiers in Pharmacology, 2017, 8:573.SCI,二区
19、Sun H , Li R , Xu S , et al. Hypothalamic Astrocytes Respond to Gastric Mucosal Damage Induced by Restraint Water-Immersion Stress in Rat[J]. Frontiers in Behavioral Neuroscience, 2016, 10.二区
20、Jia, Yanfei,Haiji Sun,Wu, Hongqiao,Zhang, Huilin,Ma, Xiaoli.Nicotine InhibitsCisplatin-Induced Apoptosis via Regulating alpha5-nAChR/AKT Signaling in HumanGastric Cancer Cells.,PLoS One,2016,11(2)。二区,第一作者
21、Haiji Sun,Xiaoli Ma,α5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells,Experimental and ToxicologicPathology,2015.四区
22、Sun, Haiji,Liu, Zhen,Ma, Xiaoli,Interactions between astrocytesand neurons in the brainstem involved in restraint water immersionstress-induced gastric mucosal damage.,Neuroreport,2016,2。四区