王若曦
日期: 2024/03/13 作者: 浏览量:
一、个人简介
王若曦,女,1991.12,副教授
教育经历:
2008.09-2012.06吉林师范大学学士
2012.09-2018.12东北师范大学博士
工作经历:
2019.03-至今js3845金沙线路
二、研究兴趣,领域:
减数分裂中染色体行为调控机制及其生物学意义。减数分裂是生殖细胞产生所必需的一种特化的细胞分裂方式,其异常是导致人类不育、流产、新生儿缺陷等严重生殖健康问题的重要因素。在减数分裂进程中,染色体的结构形态发生着显著变化,与减数分裂一系列关键事件如染色体配对、联会、同源重组等相对应。我们课题组以秀丽隐杆线虫体系为主,结合细胞生物学、遗传学、蛋白质组学等手段,探讨减数分裂染色体动态变化的结构基础和生物学意义。
三、主持科研项目:
国家自然科学基金青年基金项目,2020.01-2022.12,主持;
四、代表性论文:
1. Zhenguo Zhang#; Songbo Xie#; Ruoxi Wang#; Shuqun Guo; Qiuchen Zhao; Hui Nie; Yuanyuan Liu; Fengguo Zhang; Miao Chen; Libo Liu; Xiaoqian Meng; Min Liu; Li Zhao; Monica P.Colaiácovo; Jun Zhou; Jinmin Gao. Multivalent weak interactions between assembly units drive synaptonemal complex formation. Journal of Cell Biology, 2020, 219(5): 1-19.
2. Ruoxi Wang; Chunshuang Li; Ping Qiao; Yaoyao Xue; Xu Zheng; Hongyu Chen; Xianlu Zeng; Wenguang Liu; Istvan Boldogh; Xueqing Ba. OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos. Cell Death and Disease, 2018, 9(6): 1-15.
3. Jiaxiang Li; Jinmin Gao; Ruoxi Wang. Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation. International Journal of Molecular Sciences, 2021, 22(12271): 1-15.
4. Libo Liu; Jiaxiang Li; Yueshuang Ke; Xianlu Zeng; Jinmin Gao; Xueqing Ba; Ruoxi Wang. The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogensis. Cellular and Molecular Life Sciences, 2022, 79(60): 1-15.
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