简介：

孙爽，女，汉族，中共党员，理学博士，副教授，硕士生导师。

2022-至今，js3845金沙线路，副教授

2017-2021，js3845金沙线路，讲师

2011-2016，上海交通大学，博士

2007-2011，js3845金沙线路，学士

研究方向：一是病原微生物对宿主细胞骨架特别是微管细胞骨架的影响；二是微管结合蛋白在细胞分裂、纤毛发生等过程中的功能研究，开设课程：微生物学、微生物学实验、微生物工程。

主持或参加科研项目：

1． ENKD1在纺锤体定向中的作用及分子机制(32000490)， 国家自然科学基金青年基金，2021/01-2023/12，24万元，主持。

2． 假单胞菌的氧化应激反应在其抑菌活性中的作用（ZR2018BC002），山东省自然科学基金博士基金，2018/03-2020/12，9万元，主持。

3． OxyR调控根际假单胞菌吩嗪-1-羧酸的合成机理研究（2017M622257），第62批中国博士后基金面上项目，2017/11-2020/12，5万元，主持。

4． HDAC11去ε-氨基长链脂肪酰化机制及功能的研究(31970749)，国家自然科学基金面上项目，2020.01-2023.12，参与

5． OFIP调节有丝分裂纺锤体定向的机制与功能(31871347)， 2019.01-2022.12，参与

6． P49/STRAP与MYOCD相互作用协同调控血管平滑肌细胞表型转化的机制 (31871441)， 2019.01-2022.12，参与

代表性论文：

1. Shuang Sun, Zhaoyang Xu, Haijie Hu, Manxi Zheng, Liang Zhang, Wei Xie, Lei Sun, Peiwei Liu, Tianliang Li, Liangran Zhang, Min Chen, Xueliang Zhu, Min Liu*, Yunfan Yang*, & Jun Zhou* The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100. Sci. Signal. 2023;16(785): eade8111.

2. Shuang Sun ^*#, Jun Zhou^#. Phase separation as a therapeutic target in tight junction-associated human diseases. Acta Pharmacol Sin. 2020;41(10):1310-1313.

3. Shuang Sun, Loh Teng-Hern Tan , Yun-Ling Fang, Zi-Jing Jin, Lian Zhou, Bey-Hing Goh, Learn-Han Lee, Jun Zhou, Ya-Wen He^#. Overexpression of oxyR Increases phenazine-1-carboxylic acid biosynthesis via small rna phrs in the rhizobacterium strain Pseudomonas PA1201. Mol Plant Microbe Interact. 2020;33:488-98.

4. Haijie Hu, Min Liu, Shuang Sun^#. Pore-forming toxins during bacterial infection: Molecular mechanisms and potential therapeutic targets. Drug Des Devel Ther. 2021; 15:3773-3781

5. Shuang Sun ^*#, Jun Zhou. Molecular mechanisms underlying stress response and adaptation. Thorac Cancer. 2018;9:218-27.

6. Shuang Sun , Bo Chen, Zi-Jing Jin, Lian Zhou, Yun-Ling Fang, Chitti Thawai, Giordano Rampioni, Ya-Wen He^#. Characterization of the multiple molecular mechanisms underlying RsaL control of phenazine-1-carboxylic acid biosynthesis in the rhizosphere bacterium Pseudomonas aeruginosa PA1201. Mol Microbiol. 2017;104:931-47.

7. Shuang Sun, Lian Zhou, Kaiming Jin, Haixia Jiang, Ya-Wen He^#. Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201. Sci Rep. 2016;6:30352.

8. Zi-Jing Jin, Lian Zhou, Shuang Sun, Ying Cui, Kai Song, Xuehong Zhang, Ya-Wen He^#. Identification of a strong quorum sensing- and thermo-regulated promoter for the biosynthesis of a new metabolite pesticide phenazine-1-carboxamide in Pseudomonas strain PA1201. ACS Synth Biol. 2020;9:1802-12.

9. Lian Zhou, Shuang Sun, Wei Zhang, Ya-Wen He^#. Ultra-performance liquid chromatography/mass spectrometry for the detection and quantification of diffusible signal factor (DSF) family quorum-sensing signals. Methods Mol Biol. 2018;1673:97-105.

联系方式：shuangsun2017@sdnu.edu.cn

办公地点：js3845金沙线路博物楼，533室