聂辉

日期: 2021/01/30 作者: 浏览量:


一、个人简介

聂辉,女,汉族,生物学博士,中共党员

教育经历

2004.09-2008.06山东农业大学js3845金沙线路学士

2008.09-2014.06上海交通大学生物医学工程学院博士

工作经历

2014.07-2016.10上海宝藤医学检验所有限公司产品高级主管

2016.10-2017.08阿斯利康(中国)投资有限公司诊断专员

2017.09-今js3845金沙线路讲师

二、研究方向

减数分裂的分子机制:

减数分裂是有性生殖所必需的一种特化的细胞分裂方式,其异常是导致人类不育、流产、新生儿出生缺陷等多种生殖健康问题的重要原因。通过多种细胞生物学和分子生物学手段探索减数分裂的分子机制,从而为人类生殖健康的改善提供理论依据。

三、承担项目

1.山东省自然科学基金项目:联会复合体结合蛋白在减数分裂中的作用及分子机制(ZR2019PC050),2019.07-2022.06,主持

2.国家自然基金面上项目:联会复合体组装、维持与解聚的调控机制(31871360),2019.01-2022.12,参与

四、教学科研成果(论文、专著、专利等)

(1)Zhang Z#, Xie S#, Wang R#, Guo S, Zhao Q,Nie H, Liu Y, Zhang F, Chen M, Liu L, Meng X, Liu M, Zhao L, Colaiacovo M, Zhou J*,Gao J*. Multivalent weak interactions between assembly units drive synaptonemal complex formation. J Cell Biol. 2020 May 4; 219(5):e201910086

(2)Nie H#, Xu L#, Zhao Q#, Wang N, You C, Zhang F, Fu T, Gao H, Pan W*. Mechanisms of plant response to salinity stress: current understanding and recent progress. Par.J.Bot. 2020; 52(5):1879-83

(3)Nie H#, Hong Y#, Lu X, Zhang J, Chen H, Li Y, Ma Y, Ying W*. SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells. Neuroreport. 2014 Aug 6;25(11):838-42

(4) Ma Y#,Nie H#, Chen H#, Li J, Hong Y, Wang B, Wang C, Zhang J, Cao W, Zhang M, Xu Y, Ding X, Yin S, Qu X, Ying W*.NAD+/NADH Metabolism and NAD+-Dependent Enzymes in Cell Death and Ischemic Brain Injury: Current Advances and Therapeutic Implications.Curr Med Chem. 2015;22(10):1239-47

(5) Li Y#,Nie H#, Wu D, Zhang J, Wei X, Ying W*. Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells. Neurosci Lett. 2013 Jun 7;544:36-40.

(6) Li C#,Nie H#, Wang M, Su L, Li J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B*.MicroRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. Oncol Rep. 2012 Jun;27(6):1960-6.

(7) He X#,Nie H#, Hong Y, Sheng C, Xia W, Ying W*. SIRT2 activity is required for the survival of C6 glioma cells. Biochem Biophys Res Commun. 2012 Jan 6;417(1):468-72.